A nonhydrolyzable analogue of phosphotyrosine, and related aryloxymethano-and aryloxyethano-phosphonic acids as motifs for inhibition of phosphatases

S Iyer, JM Younker, PG Czyryca, AC Hengge

Index: Iyer, Subashree; Younker, Jarod M.; Czyryca, Przemyslaw G.; Hengge, Alvan C. Bioorganic and Medicinal Chemistry Letters, 2004 , vol. 14, # 23 p. 5931 - 5935

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Citation Number: 6

Abstract

Nonhydrolyzable analogues of both stereoisomers of phosphotyrosine, and a series of related aryloxy (or thio) methyl and aryloxy (or thio) ethyl phosphonic acids of the general formula RX–(CH2) n–PO3H2 (where X= O or S and n= 1 or 2), have been tested as nonhydrolyzable mimetics of phosphatase substrates. These compounds were tested against a panel of phosphatases (two alkaline phosphatases, a protein–tyrosine ...