Rh??Catalyzed Highly Enantioselective Hydrogenation of Nitroalkenes under Basic Conditions

…, K Huang, J Zhang, W Wu, X Zhang

Index: Li, Shengkun; Huang, Kexuan; Zhang, Jiwen; Wu, Wenjun; Zhang, Xumu Chemistry - A European Journal, 2013 , vol. 19, # 33 p. 10840 - 10844

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Abstract

Since the first report by Knowles, Horner et al. in 1968, catalytic asymmetric hydrogenation of alkenes has been one of the most powerful approaches to chiral compounds and great progress has been made.[1] Among the different alkenes, the hydrogenation of β, β- disubstituted nitroalkenes is a challenging problem. The resulting β-chiral nitroalkane from this “synthetic chameleon”[2] is a valuable synthetic scaffold. The nitro group serves as a ...

Chemoselective and enantioselective transfer hydrogenation of β, β-disubstituted nitroalkenes catalyzed by a water-insoluble chiral diamine–rhodium complex in …

[Tang, Yuanfu; Xiang, Jing; Cun, Linfeng; Wang, Yuqin; Zhu, Jin; Liao, Jian; Deng, Jingen Tetrahedron Asymmetry, 2010 , vol. 21, # 15 p. 1900 - 1905]

Asymmetric reduction of nitro olefins by fermenting bakers' yeast

[Ohta, Hiromichi; Kobayashi, Naoki; Ozaki, Kazuhiko Journal of Organic Chemistry, 1989 , vol. 54, # 8 p. 1802 - 1804]

Highly Enantioselective Hydrogenation of β, β??Disubstituted Nitroalkenes

[Li, Shengkun; Huang, Kexuan; Cao, Bonan; Zhang, Jiwen; Wu, Wenjun; Zhang, Xumu Angewandte Chemie - International Edition, 2012 , vol. 51, # 34 p. 8573 - 8576]