Synthesis and structure-activity relationships of naphthamides as dopamine D3 receptor ligands

Y Huang, RR Luedtke, RA Freeman…

Index: Huang; Luedtke; Freeman; Wu; Mach Journal of Medicinal Chemistry, 2001 , vol. 44, # 11 p. 1815 - 1826

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Citation Number: 31

Abstract

A series of naphthamides were synthesized, and the affinities of these compounds were determined for dopamine D2 and D3 receptors using radioligand binding techniques. The naphthamide compounds that were prepared include N-(1-alkylpiperidin-4-yl)-4-bromo-1- methoxy-2-naphthamides (1-6),(S)-N-(1-alkylpyrrolidin-3-yl)-4-bromo-1-methoxy-2- naphthamides (7-12),(R)-N-(1-alkylpyrrolidin-3-yl)-4-bromo-1-methoxy-2-naphthamides ( ...