Synthesis and cannabinoid activity of a variety of 2, 3-substituted 1-benzo [b] thiophen derivatives and 2, 3-substituted benzofuran: Novel agonists for the CB1 receptor

…, AD Robertson, MJ Stoermer, M Robinson, L Lay…

Index: Moloney, Gerard P.; Angus, James A.; Robertson, Alan D.; Stoermer, Martin J.; Robinson, Michael; Lay, Lucy; Wright, Christine E.; McRae, Ken; Christopoulos, Arthur Australian Journal of Chemistry, 2008 , vol. 61, # 7 p. 484 - 499

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Citation Number: 4

Abstract

Abstract An exploratory chemical effort has been undertaken to develop a novel series of compounds as selective CB 1 agonists. It is hoped that compounds of this type will have clinical utility in pain control and cerebral ischaemia following stroke or traumatic head injury. We report here medicinal chemistry studies directed towards the investigation of several classes of 1-benzo [b] thiophen and benzofuran derivatives as novel CB 1 ...