Preparation and Structure-Activity Relationships of Novel Asterriquinone Derivatives.

A Kaji, K Kimura, M Teranishi, N KIRIYAMA…

Index: Kaji, Akira; Kimura, Kengo; Teranishi, Masanori; Kiriyama, Noriki; Nomura, Masaaki; Miyamoto, Ken-Ichi Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 8 p. 1325 - 1329

Full Text: HTML

Citation Number: 12

Abstract

Asterriquinone (ARQ, 1a) is an antitumor metabolite of Aspergillus terreus IFO 6123. To gain insight into the structure-activity relationships of ARQ, a series of chemically modified derivatives (1-6), the ARQ analogues (be) and the 2, 5-dihydroxy-p-bezoquinone analogues (fh), were prepared, and cytotoxic acitivity against mouse leukemia P388 cells investigated. Results indicated that: 1) at least one hydroxy group or acetoxy group in the p- ...