Tetrahedron letters

Three component coupling catalyzed by TaCl 5–SiO 2: synthesis of α-amino phosphonates

S Chandrasekhar, SJ Prakash, V Jagadeshwar…

Index: Chandrasekhar; Prakash, S. Jaya; Jagadeshwar; Narsihmulu, Ch Tetrahedron Letters, 2001 , vol. 42, # 32 p. 5561 - 5563

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Citation Number: 191

Abstract

Of late, the synthesis and use of α-amino phosphonates have received attention as structural analogues of the corresponding α-amino acids. Peptido mimetics 1 made out of this class of compounds have shown promising pharmacological properties. 2., and They also play an important role in hapten design for antibody generation 3 and enzyme inhibitors. 4., and Thus, a variety of synthetic approaches are desirable to synthesize α-amino phosphonates. Of the ...

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