Degradation products of irradiated haloperidol: implications for the development of an implantible delivery system.

J Booker

Index: Booker Pharmazie, 1988 , vol. 43, # 1 p. 31 - 32

Full Text: HTML

Citation Number: 0

Abstract

Haloperidol was chosen as a model compound to determine whether the degradation products created by sterilizing dose of gamma radiation would contaminate an implantible delivery device and be hazardous to the health of the person using it. Acrolein, chlorobenzene, and several other products were identified among the degradation products. They were quantitated and evaluated as being potentially dangerous. It is recommended ...