Facile Palladium??Catalyzed Synthesis of 3??Arylpyrazolo [1, 5??a] pyrimidines

VJ Majo, J Prabhakaran, JJ Mann…

Index: Majo, Vattoly J.; Prabhakaran, Jaya; John Mann; Dileep Kumar Advanced Synthesis and Catalysis, 2003 , vol. 345, # 5 p. 620 - 624

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Citation Number: 9

Abstract

Abstract An efficient palladium-catalyzed synthesis of 3-arylpyrazolo [1, 5-a] pyrimidines has been investigated. The key step in the synthesis is a Suzuki biaryl coupling of 3-bromo-2, 5- dimethyl-7-aminopyrazolo [1, 5-a] pyrimidines with arylboronic acids to provide 3- arylpyrazolo [1, 5-a] pyrimidines in moderate to good yield. The synthetic utility of this methodology has been demonstrated by a concise and convergent synthesis of R121920, ...