Synthesis and biological properties of some 6H-pyrido [4, 3-b] carbazoles

S Archer, BS Ross, L Pica-Mattoccia…

Index: Archer, Sidney; Ross, Bruce S.; Pica-Mattoccia, Livia; Cioli, Donato Journal of Medicinal Chemistry, 1987 , vol. 30, # 7 p. 1204 - 1210

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Citation Number: 34

Abstract

Ellipticine, 9-hydroxyellipticine (3), and its corresponding methoacetate 8 were shown to produce DNA double and single strand breaks in LE10 cells exposed to these dr~ gs.~?~ The double strand breaks resulting from the interaction with mammalian topoisomerase I1 were reversible in L1210 cell cultures and in cell-free 9-Hydroxyellipticine (3) is the major metabolite of ellipticine in the rat. lOJ1 LePecq et a1. 2 have shown that this metabolite is ...