Structural and thermodynamic characterization of temperature-dependent changes in the folding pattern of a synthetic triamide

GP Dado, SH Gellman

Index: Dado, Gregory P.; Gellman, Samuel H. Journal of the American Chemical Society, 1993 , vol. 115, # 10 p. 4228 - 4245

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Citation Number: 82

Abstract

Abstract: Variable-temperature 'H NMR and IR studies of triamide 1 and related compounds indicate that 1 undergoes dramatic temperature-dependent conformational changes in relatively nonpolar solvents (methylene chloride and chloroform). The folding pattern favored at low temperatures in thesechlorocarbons (IC) contains a single C= O-. HN hydrogen bond in a nine-membered ring, while a folding pattern containing only a six- ...