Potential hypnotics and anxiolytics: Synthesis of 2-bromo-4-(2-chlorophenyl)-9-[4-(2-methoxyethyl) piperazino]-6H-thieno [3, 2, 4-triazolo [4, 3-a]-1, 4-diazepine and of …

Z Polívka, J Holubek, E Svátek, J Metyš…

Index: Polivka; Holubek; Svatek; et al. Collection of Czechoslovak Chemical Communications, 1984 , vol. 49, # 3 p. 621 - 636

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Citation Number: 19

Abstract

Abstract The synthesis of 2, 9-dibromo-4-(2-chlorophenyl)-6H-thieno [3, 2-f]-1, 2, 4-triazolo [4, 3-a]-1, 4, diazepine (XX) has been carried out. The substitution reactions of XX with 1-(2- methoxyethyl) piperazine, 1-(3-methoxypropyl) piperazine, 1-(2-ethoxyethyl) piperazine and 1-(2-methylthiothyl)-piperazine afforded the title compound XXIV and its analogues XXV- XXVII. N-Alkylations of 2-bromo-4-(2-chlorophenyl)-9-piperazino-6H-thieno [3, 2-f]-1, 2, 4- ...