Efficient synthesis of arylaminotetrazoles in water

D Habibi, M Nasrollahzadeh, AR Faraji, Y Bayat

Index: Habibi, Davood; Nasrollahzadeh, Mahmoud; Faraji, Ali Reza; Bayat, Yadollah Tetrahedron, 2010 , vol. 66, # 21 p. 3866 - 3870

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Citation Number: 46

Abstract

Arylaminotetrazole derivatives are synthesized efficiently by the reaction of arylcyanamides and sodium azide in the presence of ZnCl2 under aqueous conditions at reflux. Generally, isomer of 5-arylamino-1H-tetrazole can be obtained from arylcyanamides carrying electron- withdrawing substituent on aryl ring and as the electropositivity of substituent is increased, the product is shifted toward the isomer of 1-aryl-5-amino-1H-tetrazole.