Synthesis of 2??Aminobenzothiazoles via Copper (I)??Catalyzed Cross??Coupling with Part??Per??Million Catalyst Loadings
…, Y Zhang, XH Cui, W Wang
Index: Sun, Ya-Lei; Zhang, Yuan; Cui, Xiao-Hui; Wang, Wei Advanced Synthesis and Catalysis, 2011 , vol. 353, # 7 p. 1174 - 1178
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Citation Number: 15
Abstract
Abstract An efficient protocol has been developed for the preparation of 2- aminobenzothiazoles via a copper (I)-catalyzed tandem reaction of 2-iodoanilines with isothiocyanates at very low catalyst loadings [typically 50 ppm of copper (I) iodide (CuI)]. A variety of 2-iodoanilines could be cross-coupled with isothiocyanates, affording 2- aminobenzothiazoles in moderate to good yields (49–93%) under the given conditions. ...
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