Synthesis and in vitro cytotoxicity of novel long chain busulphan analogues

G Kokotos, V Constantinou-Kokotou, JM Padrón…

Index: Kokotos, George; Constantinou-Kokotou, Violetta; Padron, Jose M; Peters, Godefridus J Bioorganic and Medicinal Chemistry Letters, 2001 , vol. 11, # 6 p. 861 - 863

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Citation Number: 4

Abstract

Two novel long chain alkanediol dimethanesulphonates, analogues of busulphan, were synthesized. Their in vitro cytotoxicity was evaluated against six solid tumor cell lines (A2780, H322, LL, WiDr, C26-10 and UMSCC-22B). 2-Tetradecylbutane-1, 4-diol dimethanesulphonate was proved to be the most active compound exhibiting IC50 values between 20.82 and 26.36 μM.