Nanocrystalline copper (II) oxide catalyzed aza-Michael reaction and insertion of α-diazo compounds into N–H bonds of amines

ML Kantam, S Laha, J Yadav, S Jha

Index: Kantam, M. Lakshmi; Laha, Soumi; Yadav, Jagjit; Jha, Shailendra Tetrahedron Letters, 2009 , vol. 50, # 31 p. 4467 - 4469

Full Text: HTML

Citation Number: 41

Abstract

Nanocrystalline copper (II) oxide efficiently catalyzed the conjugate addition of aliphatic amines to α, β-unsaturated compounds to produce β-amino compounds with excellent yields under mild reaction conditions. Similarly, Glycine esters are obtained in good yields by the insertion of α-diazoacetate into N–H bonds of amines. The catalyst is used for three cycles with minimal loss of activity.