Synlett

A mild and efficient method for the one-pot monocarboxymethylation of primary amines

TJK Gibbs, M Boomhoff, NCO Tomkinson

Index: Gibbs, Timothy J. K.; Boomhoff, Michael; Tomkinson, Nicholas C. O. Synlett, 2007 , # 10 p. 1573 - 1576

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Citation Number: 10

Abstract

Abstract A mild and efficient method for the monocarboxymethylation of primary amines that takes place under aqueous conditions at room temperature is described. Treatment of an aqueous solution of a variety of primary amines with two equivalents of glyoxylic acid leads to the N-formyl glycine derivatives. Direct hydrolysis of the crude reaction solution leads to the products of amine monocarboxymethylation in good to excellent yield.