Molecular probes of DNA bulges: Functional assay and spectroscopic analysis

…, Y Lin, Z Xiao, L Kappen, IH Goldberg

Index: Jones, Graham B.; Lin, Yiqing; Xiao, Ziwei; Kappen, Lizzy; Goldberg, Irving H. Bioorganic and Medicinal Chemistry, 2007 , vol. 15, # 2 p. 784 - 790

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Citation Number: 22

Abstract

Bulged structures in DNA and RNA have been linked to biomolecular processes involved in numerous diseases, thus probes with affinity for these nucleic acid targets would be of considerable utility to chemical biologists. Herein, we report guided chemical synthesis of small molecules capable of binding to DNA bulges by virtue of their unique (spirocyclic) geometry. The agents, modeled on a natural product congener, show pronounced ...