A straightforward synthesis of cyclopropanes from aldehydes and ketones

V Gandon, P Bertus, J Szymoniak

Index: Gandon, Vincent; Bertus, Philippe; Szymoniak, Jan European Journal of Organic Chemistry, 2000 , # 22 p. 3713 - 3719

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Citation Number: 16

Abstract

Abstract A new synthetic methodology for preparing cyclopropanes is presented. The reaction involves a cooperative zirconium-and Lewis acid-mediated deoxygenative coupling of carbonyl compounds with a Grignard reagent. In this way, various cyclopropanes are obtained in moderate to excellent yields, directly from saturated, unsaturated, and aromatic aldehydes and ketones. This reaction tolerates the presence of several different functional ...

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