One??Pot Synthesis of CF3??Substituted Pyrazolines/Pyrazoles from Electron??Deficient Alkenes/Alkynes and CF3CHN2 Generated in situ: Optimized Synthesis of Tris ( …

EY Slobodyanyuk, OS Artamonov…

Index: Slobodyanyuk, Evgeniy Y.; Artamonov, Olexiy S.; Shishkin, Oleg V.; Mykhailiuk, Pavel K. European Journal of Organic Chemistry, 2014 , vol. 2014, # 12 p. 2487 - 2495

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Citation Number: 17

Abstract

Abstract The [3+ 2] cycloaddition of CF 3 CHN 2, generated in situ, with electron-deficient alkenes/alkynes affords CF 3-substituted pyrazolines/pyrazoles in quantitative yields. The one-pot three-component reaction between CF 3 CH 2 NH 2· HCl, NaNO 2, and the substrate proceeds at room temperature in dichloromethane/water.

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