Synthesis of Angularly Fused Aromatic Compounds from Alkenyl Enediynes by a Tandem Radical Cyclization Process

…, A Anoop, K Biradha, A Basak

Index: Roy, Snigdha; Anoop, Anakuthil; Biradha, Kumar; Basak, Amit Angewandte Chemie - International Edition, 2011 , vol. 50, # 36 p. 8316 - 8319

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Citation Number: 19

Abstract

The synthetic potential of the Bergman cyclization (BC)[1] has not been greatly explored despite remarkable progress in the understanding of the reaction mechanism [2] and the mode of biological action of enediynes.[3] The radicals within the 1, 4-diradical generated during the BC are distally oriented, thus preventing self-quenching, which can lead to a highly strained bicyclo system, and are spinpaired by an external quencher.[4] The 1, 4- ...

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