Aryldiones incorporating a [1, 4, 5] oxadiazepane ring. Part I: Discovery of the novel cereal herbicide pinoxaden

…, D Cornes, AA Friedmann, J Glock, T Niderman…

Index: Muehlebach, Michel; Boeger, Manfred; Cederbaum, Fredrik; Cornes, Derek; Friedmann, Adrian A.; Glock, Jutta; Niderman, Thierry; Stoller, Andre; Wagner, Trixie Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 12 p. 4241 - 4256

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Citation Number: 34

Abstract

Derivatives of the new class of 3-hydroxy-4-phenyl-5-oxo-pyrazolines were optimized towards both herbicidal activity on key annual grass weed species and selectivity in small grain cereal crops. The generic structure can be separated into three parts for the analysis of the structure–activity relationships, namely the aryl, the dione with its prodrug forms and the hydrazine moiety. Each area appears to play distinct and different roles in overall ...