Substrate specificity of pyridoxine dehydrogenase from yeast, and the synthesis and biological activities of 5-vinyl and 5-ethynyl analogs of pyridoxol

W Korytnyk, N Angelino, B Lachmann…

Index: Korytnyk; Angelino; Lachmann; Potti Journal of medicinal chemistry, 1972 , vol. 15, # 12 p. 1262 - 1265

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Citation Number: 6

Abstract

A number of 5-modified analogs of pyridoxol were found to be substrates of pyridoxine dehydrogenase. The enzyme, isolated from bakers' yeast by an improved method using DEAE-Sephadex chromatography, can readily accommodate an unbranched side chain, either saturated or unsaturated, Pyridoxol analogs were prepared with 5-vinyl by the Wittig reaction, and with 5-ethynyl by bromination and dehydrobromination of the 5-vinyl ...