Syntheses of Nα-(β-naphthylsulfonylaminoglycyl)-argininamides as potential selective synthetic thrombin inhibitors

G Etemad-Moghadam, D Delebassee…

Index: Etemad-Moghadam; Delebassee; Maffrand; Frehel European Journal of Medicinal Chemistry, 1988 ,  vol. 23,  # 6  p. 577 - 585

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Citation Number: 5

Abstract

Abstract This paper deals with the synthesis of N α-(β-naphthylsulfonylaminoglycyl)- argininamide compounds and the results of a pharmacological study (in vitro and in vivo). No thrombin inhibition was obtained with N α-arylsulfonyl-aminoalkyl-(4-amidinophenyl)- alaninamide compounds in which the 4-amidinophenylalanyl residue was substituted by an arginyl residue.