N-(Substituted Aminoacyl)-chloroanilines

E Epstein, D Kaminsky

Index: Epstein; Kaminsky Journal of the American Chemical Society, 1958 ,  vol. 80, p. 1892            

Full Text: HTML

Citation Number: 5

Abstract

Although N-(substituted aminoacy1)-anilines were prepared as early as 1891,'Einhorn2 was the first in 1898 to recognize their ability to produce a local anesthetic effect. These early compounds were too irritating for clinical use. It was not till 1946 when Lofgren3 prepared a- diethylamino-2, 6-dimethylacetanilide (lidocaine) that an anesthetic of this structure was used clinically to any extent.