The Journal of organic chemistry

Practical synthesis and elaboration of methyl 7-chloroindole-4-carboxylate

PB Alper, KLT Nguyen

Index: Alper, Phil B.; Nguyen, KhanhLinh T. Journal of Organic Chemistry, 2003 ,  vol. 68,  # 5  p. 2051 - 2053

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Citation Number: 9

Abstract

A synthesis of a previously unknown indole derivative is presented. The route reported herein allows for the preparation of multihundred gram quantities of material without any chromatographic purification. Conditions are presented for the Pd-catalyzed elaboration of one of the “diversity generating elements” of this important pharmacophore.