Synthesis and absolute configuration assignments of enantiomeric forms of ifosphamide, sulfosphamide, and trofosphamide

K Pankiewicz, R Kinas, WJ Stec, AB Foster…

Index: Journal of the American Chemical Society, , vol. 101, p. 7712 - 7718

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Citation Number: 42

Abstract

... Journal of the American Chemical Society 1 101:26 ... The successful conversion of 16 to 2 inspired us to use the same approach to the synthesis of the enantiomers of trofos- phamide (3). Reaction of 1(S) and 1(R) with chloroacetyl chloride gave 2- [bis(2-chloroethyl)amino]-3 ...