Tetrahedron

Synthesis of new inhibitors of aldosterone biosynthesis

A Viger, S Coustal, S Perard, A Marquet

Index: Viger, Antoinette; Coustal, Suzy; Perard, Serge; Marquet, Andree Tetrahedron, 1988 ,  vol. 44,  # 4  p. 1127 - 1134

Full Text: HTML

Citation Number: 15

Abstract

The synthesis of 18 vinyl and 18 ethynylprogesterone 1 and 2 is described. The reported data emphasize the decisive role played by the protective group on carbon 3 in the course of reactions taking place at the angular 18 methyl group. Compounds 1 and 2, designed as kcat inhibitors of aldosterone biosynthesis late step show substantial in vitro activity.