A radiotracer for mapping cholinergic neurons of the brain

YW Jung, ME Van Dort, DL Gildersleeve…

Index: Jung; Van Dort; Gildersleeve; Wieland Journal of Medicinal Chemistry, 1990 ,  vol. 33,  # 8  p. 2065 - 2068

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Citation Number: 69

Abstract

Racemic IBVM4 was synthesized from (&)-5-aminobenzovesamicol (1)'by diazotization and reaction with potassium iodide (Scheme I). Reaction of (d=)-IBVM with (-)-(S)-a-methoxy-a- (trifluoromethy1) phenylacetyl (MTPA) chloride5 gave a mixture of the diastereomeric esters 2 and 4; separation of the esters was achieved by preparative TLC on silica gel after several developments with hexane/EtOAc (19/l). 6 Base hydrolysis of the MTPA esters provided ...