Thermolysin-catalyzed synthesis of peptide amides.

K SAKINA, K KAWAZURA, K MORIHARA…

Index: Sakina; Kawazura; Morihara; Yajima Chemical and Pharmaceutical Bulletin, 1988 ,  vol. 36,  # 11  p. 4345 - 4354

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Citation Number: 15

Abstract

Enzymatic condensation by thermolysin between various amino acid amides and Naprotected or unprotected peptides was examined. As models, three protected tetrapeptide amides, Boc-Trp-Met-Asp-X, Boc-Ser-Glu-Ala-X and Boc-Ser-Lys-Ala-X, and two unprotected tetrapeptide amides, H-Trp-Met-Asp-X and H-Phe-Met-Arg-X, were prepared [X= Phe-NH 2, Leu-NH 2, Phe-NHEt, Val-NH 2, Ala-NH 2,(p-fluoro) Phe-NH 2], and the ...