Synthesis and biological evaluation of new symmetrical derivatives as cytotoxic agents and apoptosis inducers

…, E Cubedo, J García-Foncillas, M Font, JA Palop

Index: Sanmartin, Carmen; Echeverria, Mikel; Mendivil, Beatriz; Cordeu, Lucia; Cubedo, Elena; Garcia-Foncillas, Jesus; Font, Maria; Palop, Juan Antonio Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 6 p. 2031 - 2044

Full Text: HTML

Citation Number: 46

Abstract

Based on the research of less toxic anticancer therapies, we have looked for novel compounds with anticancer activity based on a proapoptotic mechanism. The described compounds are derivatives of ether, carbamate, urea, amide, or amine. Some of the prepared compounds decreased cell viability of various tumor cell lines in a time-and dose- dependent manner, and also induced DNA fragmentation, which indicated cell apoptosis. ...