Tetrahedron

Chemoenzymatic preparation of optically active 4-aryl-5-carboxy-6-methyl-3, 4-dihydro-2 (1H)-pyridone derivatives

SY Torres, E Ochoa, Y Verdecia, F Rebolledo

Index: Torres, Susana Y.; Ochoa, Estael; Verdecia, Yamila; Rebolledo, Francisca Tetrahedron, 2014 , vol. 70, # 31 p. 4675 - 4684

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Citation Number: 3

Abstract

Abstract A series of racemic 4-aryl-5-(tert-butoxycarbonyl)-6-methyl-3, 4-dihydro-2 (1H)- pyridones have been prepared by means of a modified Hantzsch reaction using commercially available starting materials. An easy removal of the tert-butyl group of these pyridones and subsequent reaction with cesium carbonate and chloromethyl 2- methylpropanoate provided us suitable substrates (±)-5 to be used in lipase-catalyzed ...