Tetrahedron

Efficient copper-catalyzed C–S cross-coupling of heterocyclic thiols with aryl iodides

LF Niu, Y Cai, C Liang, XP Hui, PF Xu

Index: Niu, Liang-Feng; Cai, Yan; Liang, Chao; Hui, Xin-Ping; Xu, Peng-Fei Tetrahedron, 2011 , vol. 67, # 16 p. 2878 - 2881

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Citation Number: 28

Abstract

A copper-catalyzed cross-coupling of heterocyclic thiols with aryl iodides is reported. The reaction was carried out in the presence of CuI (5 mol%), 1, 10-phenanthroline (10 mol%) and K2CO3 (1.3 equiv) in DMF at 120° C. A variety of heterocyclic sulfides were prepared in high selectivities and yields.

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