Enzymic preparation of an optically active phosphotriester, asymmetric only at phosphorus

NPB Dudman, B Zerner

Index: Dudman,N.P.B.; Zerner,B. Journal of the American Chemical Society, 1973 , vol. 95, # 9 p. 3019 - 3021

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Citation Number: 14

Abstract

asymmetric at the phosphorus atom. Such esters promise to be of special value in determining the steric courses and kinetics of reactions of phosphoric acid esters, and thus for evaluating any influence of pseudorotation on their chemistry. The stereospecificity of a wide variety of enzymes can also be studied using optically active phosphotriesters, which may lead to an understanding of the biological relationships between these enzymes.