The synthesis of a Nγ??phthalyl??Nα??methyl?螃?, γ??diaminobutyryl congener of virginiamycin S1

MJO Anteunis, C Van der Auwera…

Index: Anteunis, M. J. O.; Auwera, C. Van der; Vanfleteren, L.; Borremans, F. Bulletin des Societes Chimiques Belges, 1988 , vol. 97, # 2 p. 135 - 148

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Citation Number: 8

Abstract

Abstract A synthesis of Z-Thr 1-D-Abu 2-Pro 3-MePhe 4-MeA 2 bu (γPht) 5-Phg 6-(A 2 bu= α, γ-diaminobutyric acid) is reported using the very efficient coupling agent BOP-Cl (N, N'-bis (3- oxo-2-oxazolidinyl) phosphinic chloride) for imino acid peptide bond formation. The total yield is 11% for the 5 coupling steps and one lactonization. The final step was a cyclization between residues 5 and 6, after (i) first t-Boc acidic deprotection with 85% HCOOH of the ...