Novel hybrid selenosulfonamides as potent antileishmanial agents

…, M Font, KJ Gutierrez, A Jiménez-Ruiz, JA Palop…

Index: Baquedano, Ylenia; Moreno, Esther; Espuelas, Socorro; Nguewa, Paul; Font, Maria; Gutierrez, Kilian Jesus; Jimenez-Ruiz, Antonio; Palop, Juan Antonio; Sanmartin, Carmen European Journal of Medicinal Chemistry, 2014 , vol. 74, p. 116 - 123

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Citation Number: 9

Abstract

Abstract Diselenide and sulfonamide derivatives have recently attracted considerable interest as leishmanicidal agents in drug discovery. In this study, a novel series of sixteen hybrid selenosulfonamides has been synthesized and screened for their in vitro activity against Leishmania infantum intracellular amastigotes and THP-1 cells. These assays revealed that most of the compounds exhibited antileishmanial activity in the low ...