Tetrahedron Letters

Novel solid-phase synthesis of 1, 5-benzothiazepine-4-one derivatives

GC Morton, JM Salvino, RF Labaudinière, TF Herpin

Index: Morton, George C.; Salvino, Joseph M.; Labaudiniere, Richard F.; Herpin, Timothy F. Tetrahedron Letters, 2000 , vol. 41, # 17 p. 3029 - 3033

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Citation Number: 31

Abstract

A new solid-phase efficient route to 1, 5-benzothiazepine-4-one derivatives is reported. The synthesis exploits the variety of halo-nitrobenzene derivatives available and the facile substitution of the benzamide nitrogen. A wide range of derivatives can be obtained in excellent purity.