Novel 5-hydroxytryptamine (5-HT3) receptor antagonists. III. Pharmacological evaluations and molecular modeling studies of optically active 4, 5, 6, 7-tetrahydro-1H- …

M OHTA, T SUZUKI, T FURUYA, H KURIHARA…

Index: Chemical and Pharmaceutical Bulletin, , vol. 44, # 9 p. 1707 - 1716

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Citation Number: 21

Abstract

... 13) and granisetron 24' are already in clini- cal use to suppress vomiting aSSociated with cancer Chemistry chemotherapy (Chart 1 ... of radio-ligand binding data using 0 Me n potent agents, including 1 and 2, Regarding the chemical N/\< ' CNH ... (0 1996 Pharmaceutical Society of ...