Enzymatic kinetic separation of stereoisomeric macrocyclic lactone derivatives, 7α, β-O-acyl trans-zearalenols and 7α, β-O-acyl zearanols

M Gelo, V Šunjić

Index: Gelo, Mirjana; Sunjic, Vitomir Tetrahedron, 1992 , vol. 48, # 31 p. 6511 - 6520

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Citation Number: 11

Abstract

Diastereomeric mixtures of resorcyclic acid macrocyclic lactones, 7α, β-O-acyl zearalenols (1, 2 and 3, 4 full name: trans-3, 4, 5, 6, 9, 10-octahydro-14, 16-dihydroxy-7-acyloxy-3-methyl 1H-2-benzoxacyclotetradecin-1-ones (3S, 7S or 3S, 7R)), and 7α, β-acyl zearanols (5, 6 and 7, 8, full name: 3, 4, 5, 6, 9, 10, 11, 12-decahydro-14, 16-dihydroxy-7-acyloxy-3-methyl-1H-2- benzoxacyclotetradecin-1-ones (3S, 7S or 3S, 7R)) are hydrolyzed by lipases. Kinetic ...