Synthesis and evaluation of pN, N-dialkyl substituted chalcones as anti-cancer agents

…, JS Kumar, C Bicknese, JL Johnson, M Williams

Index: Nelson, Grady; Alam, Mohammad A.; Atkinson, Tyler; Gurrapu, Shirisha; Sravan Kumar; Bicknese, Chris; Johnson, Joseph L.; Williams, Michael Medicinal Chemistry Research, 2013 , vol. 22, # 10 p. 4610 - 4614

Full Text: HTML

Citation Number: 8

Abstract

Abstract Several new N, N-dialkyl substituted chalcones (chalconoids or benzylideneacetophenones) have been synthesized via the condensation of corresponding N, N-dialkylbenzaldehyde with various aryl methyl ketones. All the chalcones have been synthesized from readily available and cheap starting materials under environmentally benign conditions in very high yields without work up and column chromatographic ...

Related Articles:

Palladium catalyzed N-alkylation of amines with alcohols

[Zhang, Yan; Qi, Xiujuan; Cui, Xinjiang; Shi, Feng; Deng, Youquan Tetrahedron Letters, 2011 , vol. 52, # 12 p. 1334 - 1338]

Direct One??Pot Reductive N??Alkylation of Nitroarenes by using Alcohols with Supported Gold Catalysts

[Tang, Chun-Hong; He, Lin; Liu, Yong-Mei; Cao, Yong; He, He-Yong; Fan, Kang-Nian Chemistry - A European Journal, 2011 , vol. 17, # 26 p. 7172 - 7177]

Solvent-and catalyst-free direct reductive amination of aldehydes and ketones with Hantzsch ester: synthesis of secondary and tertiary amines

[Nguyen, Quynh Pham Bao; Kim, Taek Hyeon Tetrahedron, 2013 , vol. 69, # 24 p. 4938 - 4943]

Potassium iodide catalysed monoalkylation of anilines under microwave irradiation

[Romera, Juan L.; Cid, Jose M.; Trabanco, Andres A. Tetrahedron Letters, 2004 , vol. 45, # 48 p. 8797 - 8800]

Synthesis of 2, 3-Dihydroindoles, Indoles, and Anilines by Transition Metal-Free Amination of Aryl Chlorides

[Beller; Breindl; Riermeier; Tillack Journal of Organic Chemistry, 2001 , vol. 66, # 4 p. 1403 - 1412]

More Articles...