Cysteine based novel noncompetitive inhibitors of urease (s)—Distinctive inhibition susceptibility of microbial and plant ureases

Z Amtul, N Kausar, C Follmer, RF Rozmahel…

Index: Amtul, Zareen; Kausar, Naheed; Follmer, Cristian; Rozmahel, Richard F.; Atta-Ur-Rahman; Kazmi, Syed Arif; Shekhani, Mohammed Saleh; Eriksen, Jason L.; Khan, Khalid M.; Choudhary, Mohammad Iqbal Bioorganic and Medicinal Chemistry, 2006 , vol. 14, # 19 p. 6737 - 6744

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Citation Number: 16

Abstract

Based on the catalysis mechanism of urease, a homologous series of 10 cysteine derivatives (CysDs) was designed and synthesized, and their inhibitory activities were evaluated for microbial ureases (Bacillus pasteurii, BPU, and Proteus mirabilis, PMU) and for a plant urease [jack bean (Cavavalia ensiformis), JBU]. As already described, thiol- compounds might inhibit urease activity by chelating the nickel atoms involved in the ...