Tetrahedron letters

Alkylation of Rink's amide linker on polystyrene resin: A reductive amination approach to modified amine-linkers for the solid phase synthesis of N-substituted amide …

EG Brown, JM Nuss

Index: Brown, Edward G.; Nuss, John M. Tetrahedron Letters, 1997 , vol. 38, # 49 p. 8457 - 8460

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Citation Number: 53

Abstract

Reductive amination of aldehydes and ketones using sodium cyanoborohydride and Rink's 4-(2′, 4′-dimethoxyphenyl-aminomethyl)-phenoxymethyl-linked polystyrene resin [Rink's amine linker on copoly-(styrene-1%-divinylbenzene)] 12 affords high yields of linker-bound, N-alkyl amines with excellent chemical selectivity. Subsequent coupling with acid derivatives gave derivatized N-substituted amides in excellent yields after cleavage from ...

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