The first example of molecularly imprinted nanogels with aldolase type I activity

…, A Servant, V Gouverneur, M Resmini

Index: Carboni, Davide; Flavin, Kevin; Servant, Ania; Gouverneur, Veronique; Resmini, Marina Chemistry - A European Journal, 2008 , vol. 14, # 23 p. 7059 - 7065

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Citation Number: 80

Abstract

Abstract The molecular-imprinting approach was used to obtain a nanogel preparation capable of catalysing the cross-aldol reaction between 4-nitrobenzaldehyde and acetone. A polymerisable proline derivative was used as the functional monomer to mimic the enamine- based mechanism of aldolase type I enzymes. The diketone template used to create the cavity was designed to imitate the intermediate of the aldol reaction and was bound to the ...