Evaluation of the effects of the enantiomers of reduced haloperidol, azaperol, and related 4-amino-1-arylbutanols on dopamine and. sigma. receptors

JC Jaen, BW Caprathe, TA Pugsley…

Index: Jaen; Caprathe; Pugsley; Wise; Akunne Journal of Medicinal Chemistry, 1993 , vol. 36, # 24 p. 3929 - 3936

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Citation Number: 36

Abstract

D2 and D3 receptors is quite similar to that of 3a,(S)-(-)-3b being about 4 times more potent than ita enantiomer at both receptors.(R)-(+)-3b binds preferentially to u S1 over S2 sites, while (S)-(-)-3b displays the opposite selectivity profile. Both enantiomers of 3c possess very weak affinity for D2 and D3 receptors. In a manner similar to the enantiomers of 3b, the affinity of (R)-(+)-3c is greater for S1 than S2 sites, while (S)-(-)-3c displays the opposite ...