Highly efficient cyclosarin degradation mediated by a β-cyclodextrin derivative containing an oxime-derived substituent

M Zengerle, F Brandhuber, C Schneider…

Index: Zengerle, Michael; Brandhuber, Florian; Schneider, Christian; Worek, Franz; Reiter, Georg; Kubik, Stefan Beilstein Journal of Organic Chemistry, 2011 , vol. 7, p. 1543 - 1554

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Citation Number: 25

Abstract

Abstract The potential of appropriately substituted cyclodextrins to act as scavengers for neurotoxic organophosphonates under physiological conditions was evaluated. To this end, a series of derivatives containing substituents with an aldoxime or a ketoxime moiety along the narrow opening of the β-cyclodextrin cavity was synthesized, and the ability of these compounds to reduce the inhibitory effect of the neurotoxic organophosphonate cyclosarin ...

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