An advanced method for the preparation of 2, 6-dichlorodiphenylamine and its N-chloroacetyl derivative—Intermediates in the synthesis of antiinflammatory drug …

…, IP Isakovich, VA Kuzovkin, NB Grigor'ev…

Index: Ryabova; Bokanov; Isakovich; Kuzovkin; Grigor'ev; Levina; Shvedov; Granik Pharmaceutical Chemistry Journal, 1996 , vol. 30, # 1 p. 38 - 40

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Abstract

It is known that 2, 6-dichlorodiphenylamine (II) is the main intermediate in the synthesis of ortophenum (I)(voltaren, diciofenac sodium)[1]. Compound II is used to prepare I by N- chioroacetylation to obtain III, which is subjected to Friedel-Crafts cyclization. The obtained l- (2, 6-dichlorophenyl) indolin-2-one (IV) is then subjected to alkaline bydrolysis to yield I. i~ CH2CI

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