Chemical tagging of a drug target using 5-sulfonyl tetrazole

…, H Takabatake, K Nakajima, Y Takasu, T Yagura…

Index: Otsuki, Satsuki; Nishimura, Shinichi; Takabatake, Hisae; Nakajima, Kozue; Takasu, Yasuaki; Yagura, Toru; Sakai, Yuki; Hattori, Akira; Kakeya, Hideaki Bioorganic and Medicinal Chemistry Letters, 2013 , vol. 23, # 6 p. 1608 - 1611

Full Text: HTML

Citation Number: 9

Abstract

Irreversible modification is one of the most promising strategies to identify cellular receptors of bioactive small molecules. Here we report that receptor proteins can be chemically tagged using a 5-sulfonyl tetrazole probe. 5-Sulfonyl tetrazole easily accepted nucleophilic attack of thiol groups, while 5-sulfinyl tetrazole did not. These functional groups were introduced into probe molecules of a natural product. Cyclosporine A, an immunosuppressant produced ...

Related Articles:

Development and characterization of a promising fluorine-18 labelled radiopharmaceutical for in vivo imaging of fatty acid amide hydrolase

[Sadovski, Oleg; Hicks, Justin W.; Parkes, Jun; Raymond, Roger; Nobrega, Jose; Houle, Sylvain; Cipriano, Mariateresa; Fowler, Christopher J.; Vasdev, Neil; Wilson, Alan A. Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 14 p. 4351 - 4357]

Development and characterization of a promising fluorine-18 labelled radiopharmaceutical for in vivo imaging of fatty acid amide hydrolase

[Sadovski, Oleg; Hicks, Justin W.; Parkes, Jun; Raymond, Roger; Nobrega, Jose; Houle, Sylvain; Cipriano, Mariateresa; Fowler, Christopher J.; Vasdev, Neil; Wilson, Alan A. Bioorganic and Medicinal Chemistry, 2013 , vol. 21, # 14 p. 4351 - 4357]

More Articles...