Conjugation of an oligonucleotide to Tat, a cell-penetrating peptide, via click chemistry
SD Brown, D Graham
Index: Brown, Sarah D.; Graham, Duncan Tetrahedron Letters, 2010 , vol. 51, # 38 p. 5032 - 5034
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Citation Number: 18
Abstract
Uptake of diagnostic and therapeutic oligonucleotides that specifically target disease can be enhanced by attachment of a cell-penetrating peptide. Here, we describe the covalent attachment of an oligonucleotide to Tat, a biologically important cell-penetrating peptide, via click chemistry.
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