Tetrahedron

Study of the catalytic properties of tris (3, 6-dioxaheptyl) amine (TDA-1) in heteroaromatic nucleophilic substitution of chloropyridines and their N-oxides

P Ballesteros, RM Claramunt, J Elguero

Index: Ballesteros, P.; Claramunt, R.M. Tetrahedron, 1987 , vol. 43, # 11 p. 2557 - 2564

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Citation Number: 23

Abstract

Catalytic properties of tris (3, 6-dioxaheptyl) amine (TDA-1) have been analyzed in reactions of alkoxydehalogenation of 2-and 4-chloropyridine and their N-oxides under solid-liquid phase transfer catalysis conditions. Alkoxypyridines were obtained in excelent yields but with N-oxides a competitive alkaline cleavage of the performed ether was observed.