Structure-activity relationships of 2-(benzothiazolylthio) acetamide class of CCR3 selective antagonist

…, K Kobayashi, M Ishikawa, K Ohwaki, T Saeki…

Index: Naya, Akira; Kobayashi, Kensuke; Ishikawa, Makoto; Ohwaki, Kenji; Saeki, Toshihiko; Noguchi, Kazuhito; Ohtake, Norikazu Chemical and Pharmaceutical Bulletin, 2003 , vol. 51, # 6 p. 697 - 701

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Citation Number: 39

Abstract

The structure activity relationships of novel selective CCR3 receptor antagonists, 2- (benzothiazolylthio) acetamimde derivatives were described. A lead structure (1a) was discovered from the screening of the focused library that was based on the structure of our dual antagonists for the human CCR1 and CCR3 receptors. Derivatization of 1a including incorporation of substituent (s) into each benzene ring of the benzothiazole and piperidine ...