TBAF-assisted copper-catalyzed N-arylation and benzylation of benzazoles with aryl and benzyl halides under the ligand/base/solvent-free conditions

…, KJ Jung, BR Kim, SG Lee, YJ Yoon

Index: Lee, Hyung-Geun; Won, Ju-Eun; Kim, Min-Jung; Park, Song-Eun; Jung, Kwang-Ju; Bo, Ram Kim; Lee, Sang-Gyeong; Yoon, Yong-Jin Journal of Organic Chemistry, 2009 , vol. 74, # 15 p. 5675 - 5678

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Citation Number: 33

Abstract

TBAF-assisted N-arylation and benzylation of benzazoles such as 1 H-benzimidazole, 1 H- indole, and 1 H-benzotriazole with aryl and benzyl halides have been demonstrated under the ligand/base/solvent-free conditions. In the presence of CuBr2 and TBAF (n-Bu4NF), the azoles underwent N-arylation and benzylation with aryl and benzyl halides smoothly in moderate to good yields. It is noteworthy that the reaction is conducted under the ligand/ ...

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